By preserving the integrity and functionality of the nucleus, they provide cellular mechanism as new light on a crucial system that regulates physical and reproductive aging.
Greek scientists have discovered a novel chemical process that controls cell aging and fertility.
The results of researchers from the Institute of Molecular Biology and Biotechnology (IMBB) of the Foundation for Research and Technology – Hellas were published in the international scientific journal Nature on Tuesday (FORTH).
The underlying process that maintains the integrity and functionality of the nucleus and controls physical and reproductive aging is made clear by them for the first time. The synthesis of the ribosome, which produces protein in the cell, takes place in the nucleus. Longevity is linked to the nucleus’s tiny size.
Sarcopenia has been associated with a number of molecular processes that pertain to quite varied levels of muscle physiology. These systems include mitochondrial activity and proteostasis, muscle fiber composition and neuromuscular drive, myo-satellite cell potential for differentiation and proliferation, inflammatory pathways, and hormone function. However, the chemical and cellular operations that modify the nucleus are still not well known.
Several Cellular Mechanism Regulates Aging And Fertility
Several molecular mechanisms have been described as causes for sarcopenia that refer to very different levels of muscle physiology. These mechanisms cover e. g. function of hormones, muscle fiber composition and neuromuscular drive, myo-satellite cell potential to differentiate and proliferate, inflammatory pathways as well as intracellular mechanisms in the processes of proteostasis and mitochondrial function.
Through their research, the IMBB researchers show how closely related protein production is to how quickly a person ages. One of the most energy-intensive biological processes, protein synthesis uses about 50% of the total energy generated by the cell.
Reduced protein synthesis would result in an energy excess that might be used to fund cellular repair and maintenance systems. Hence it boosting survival. In fact, IMBB researchers were able to significantly increase the lifespan of the nematode. They C. elegans by controlling the rate of protein synthesis. This is the first time that protein production and aging are connected directly.